On Wednesday at Arthur Ashe Stadium, Williams defeated World No. 2 Anett Kontaveit 7-6(4), 2-6, 6-2 in front of yet another boisterous, uproarious record crowd.
The winner of 23 singles titles at majors, Serena has now won 107 matches in New York, and 102 of them have come in Arthur Ashe Stadium, according to wtatennis.com
The William sisters are two-time champions at the U.S Open and will pair for the first time since 2018 Roland Garros.
Williams revealed earlier this month that she would be retiring after the U.S. Open. She has won six titles in New York and will play No. 80 Kovinic for the first time.
Williams was broken in the first game of the match by 19-year-old Raducanu, who quickly dominated and went on to win 6-4, 6-0.
If Swiatek wins in Cincinnati, she will become the first player since Williams in 2013 to lift seven titles before the US Open.
The 40-year old Williams, who is more than two decades older than her 19-year-old opponent, was the top-ranked player in the world when Raducanu was born in November of 2002.
The 41-year-old has decided to hang up her boots after the upcoming 2022 US Open because of her personal decision to focus more on her family.
While Swiatek will aim for her second Grand Slam title of the year after clinching the French Open title as part of an incredible 37-match winning streak, Serena, who has won 23 Grand Slam singles titles in her career.