The Serbian became the fifth man in the Open Era to earn 1,000 match wins when he defeated Casper Ruud in the semi-finals and he backed that up with a hard-fought display against Tsitsipas to win his first title of the season after one hour and 37 minutes.
Tsitsipas' 31st victory of 2022 extends his lead over second-placed Carlos Alcaraz (28) on the season's match win leaderboard. Tsitsipas' run to the Rome semi-finals has propelled him to No. 4 in the Live ATP Rankings
Iga Swiatek has now won 39 of her last 40 sets, and her incredible winning streak now stands at 27 matches. She is now tied with Serena Williams for the century's fourth-longest winning streak. From the 2014 WTA Finals to the 2015 Madrid Open, Williams won 27 matches.
After 75 minutes, the Serbian soaked up Wawrinka's heavy ball-striking and pulled the former World No 3 around to advance to the quarter-finals.
The Spaniard, beaten by Carlos Alcaraz in last week's Madrid Open quarterfinals, returned to his favourite surface with straight sets win over American Isner.
In the process, Swiatek, stretched her run to 24 matches, the longest streak since Serena Williams won 27 straight matches in 2015.
In Madrid, the Spanish teenager defeated Rafael Nadal and Novak Djokovic back-to-back before thrashing Alexander Zverev in the final on Sunday for his fourth title of the year.
The draw, which was released late on Friday, had world No.1 Iga Swiatek headlining the field. Swiatek could face 16th seed Victoria Azarenka of Belarus in the tournament's Round of 16, while 10th seed Emma Raducanu of the United Kingdom could face fifth seed Anett Kontaveit of Estonia.
The best of players from all across the globe come to take part in the Italian Open played at the outdoor clay courts of Foro Italico. However, the report said that Italian authorities "are reportedly weighing up whether a ban should be imposed on Russian players" at the tournament.
