The Rohan-Rutuja duo struggled in the initial set of the match and lost the first set against Chinese Taipei's En-shuo Liang and Tsung-hao Huang by 6-2.
It was a mixed day for India at the US Open as Rohan Bopanna advanced to the second round with his Canadian partner Denis Shapovalov while Leander Paes and his Argentine partner Guillermo Duran failed to progress after suffering a first-round loss in the men’s doubles event.
Bopanna and Shapovalov defeated formidable fourth-seeded French pair of Pierre-Hugues Herbert and Nicolas Mahut 6-3, 6-1 in a match that lasted just 55 minutes. They will now face the Italian pair of Andreas Seppi and Marco Cecchinato on Saturday.
In the other men’s doubles match, Paes and Duran lost 5-7, 2-6 to Serbia’s Miomir Kecmanovic and Norway’s Casper Ruud to bow out of the competition.