Ramos-Vinolas, ranked 24 in the world, defeated the Briton 2-6, 6-2, 7-5 in two hours and 32 minutes.
World No.1 Andy Murray was knocked out on Thursday from the Monte-Carlo Masters, after suffering a shock defeat against Spain's Albert Ramos-Vinolas in the men's singles pre-quarterfinals.
Ramos-Vinolas, ranked 24 in the world, defeated the Briton 2-6, 6-2, 7-5 in two hours and 32 minutes, reports Efe.
Murray, 29, who recently returned from time off the court due to injury, failed to keep up with the Spaniard's pace and only managed to win the first set before losing a disappointing second set, and eventually losing the match and a place in the quarterfinals.
Ramos-Vinolas will play the last eight match against Croatia's Marin Cilic, World No.8, who eliminated Czech Tomas Berdych after a 6-2, 7-6 (7-0) victory.