— Manchester United (@ManUtd) March 13, 2018
United boss Jose Mourinho has kept Anthony Martial and Paul Pogba on the bench, but has recalled Marouane Fellaini into the starting XI as the hosts trot out in a 4-2-3-1 formation.
David de Gea retains his place between the sticks, behind a four-man defence of Antonio Valencia, Eric Bailly, Chris Smalling and Ashley Young.
Nemanja Matic partners Fellaini in central midfield while Jesse Lingard, Alexis Sanchez and Marcus Rashford line up behind Romelu Lukaku in attack.
— Sevilla Fútbol Club (@SevillaFC) March 13, 2018
Sevilla manager Vincenzo Montella is sending out his side in a formation that mirrors United’s, with Luis Muriel leading the line.
Joaquin Correa, Franco Vazquez and Pablo Sarabia feature behind Muriel, while Ever Banega and Steven Nzonzi anchor the midfield.
Sergio Escudero, Clement Lenglet, Simon Kjaer and Gabriel Mercado start in front of custodian Sergio Rico.
The first leg in Seville ended in a 0-0 draw, with the Spanish side dominating but unable to make the most of the chances that fell their way and United are favourites to make the quarters in front of their own fans.
After wins over rivals Chelsea and Liverpool in the Premier League, the Red Devils are riding a surge of self-belief but it remains to be seen if their domestic success will translate into victory in continental competition.
Manchester United: De Gea, Valencia (c), Bailly, Smalling, Young, Matic, Fellaini, Lingard, Alexis, Rashford and Lukaku.
Sevilla: Sergio Rico, Escudero, Kjaer, Lenglet, Banega, Correa, Nzonzi, Sarabia, Muriel, Vazquez and Mercado.
Match kicks-off at 20.45 GMT/01.15 IST.